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Erythropoiesis is the highly regulated multistep process, the end product of which is the erythrocytes or red blood cells. Stem cells have extensive proliferative capacity and also the: - Ability to give rise to new stem cells (Self Renewal) - Ability to differentiate into any blood cells lines (Pluripotency) stem cells are regulated by certain hormones or substances so that they can Erythropoietin (EPO) is a hormone produced primarily by the kidneys, with small amounts made by the liver. EPO plays a key role in the production of red blood cells (RBCs), which carry oxygen from the lungs to the rest of the body. This test measures the amount of erythropoietin in the blood. The body uses a dynamic feedback system to help Testosterone levels tend to drop with increasing age; because of this, men tend to experience a decrease in testicular size, a drop in libido, lower bone density, muscle mass decline, increased fat production, and decreased erythropoiesis, which leads to possible anemia. Mechanism poxia response element (HRE) of the erythropoietin gene under hypoxic conditions.2 It subsequently became clear that hypoxia-inducible factor 1 (HIF-1) is a dimer consisting of HIF-1α and HIF-1β Serum erythropoietin (Epo) was measured by enzyme-linked immunosorbent assay (R&D Systems, Minneapolis, MN). Tissue Iron Concentrations Liver and spleen specimens were analyzed for non-heme iron content by the bathophenanthroline method of Torrance and Bothwell ( Torrance et al., 1980) as previously described ( Fleming et al., 2001 ). Description. Guyton and Hall Textbook of Medical Physiology continues this bestselling title's tradition as one of the world's favourite physiology textbooks. The main aim of the South Asian Edition of Guyton & Hall Textbook of Medical Physiology is to meet the needs of undergraduate medical students and faculty in South Asia in alignment erythropoiesis happens in several tissues such as the liver [23]. Fetal liver, in fact, connected early erythroid cells and CD105-endothelial cells that are precursors of circulating cells and which reside in the bone marrow after the birth. The testis tissues still appeared unconnected to any other tissue. The cluster of 15 CNS Hematology 1) Erythropoiesis From yolk sac: 3 weeks From liver: 10 weeks From bone marrow and spleen: term (90%) EPO production: 32 nd week Development of embryo and fetus 2) Fetal hemoglobin Fetal hemoglobin: early pregnancy Adult hemoglobin: 32 nd week Term: fetal type Hb 25% 3) White cells Leukocytes: 8 week Lymphocytes (antibody production): 12 week, thymus and spleen Development of embryo and fetus 3. In fetal life, the erythropoiesis occurs in three stages: 1.Mesoblastic Stage 2.Hepatic Stage 3.Myeloid Stage ERYTHROPOIESIS 11. In newborn babies, growing children and adults, RBCs are produced only from the red bone marrow. 1. Red bone marrow 2. Yellow bone marrow ERYTHROPOIESIS 12. STAGES OF ERYTHROPOIESIS 1. Proerythroblast 2. one of the major determinants of aerobic performance is the athletes' capacity to deliver oxygen to the tissues. Endurance training
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