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AMD software and drivers are designed to work best for up-to-date operating Please be sure to update your operating system before installing drivers. Start the computer and then install the new drivers and software. 3. Restart the computer. Installing the Graphics Card. 1. Turn off the computer, monitor(s) SAPPHIRE's website uses cookies to enhance site visitor experience Visit Privacy for information on how to disable cookies. I Accept. Radeon RX 6900 Manual Radeon HD 6450 Driver Update Instructions: Basic versions of your Radeon HD 6450 drivers are included with your Windows or through installing theManuals and User Guides for AMD Radeon HD 6450. We have 1 AMD Radeon HD 6450 manual available for free PDF download: User Manual · 5. Table of Contents · 7.